Handbook of the Behavioral Neurobiology of Serotonin
Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional component
1 online resource (849 pages).
9780080878171, 0080878172
1049559445
Front Cover; Handbook of the Behavioral Neurobiology of Serotonin; Copyright Page; Contents; Preface; List of Contributors; Section 1: Functional Anatomy of the Serotonergic System; Chapter 1.1 Evolution of Serotonin: Sunlight to Suicide; Introduction; Tryptophan; Serotonin; Summary; Acknowledgements; References; Chapter 1.2 Genetic Organization of the Serotonergic System; Introduction; Subfamilies of 5-HT receptors; Tryptophan hydroxylase genes; Serotonin transporter gene (SERT, 5-HTT, SLC6A4); Brain-derived neurotrophic factor gene (BDNF); Monoamine oxidase genes (MAO); Conclusions. AcknowledgementsReferences; Chapter 1.3 The Neuroanatomy of the Serotonergic System; Introduction; Divisions of the raphe and associated serotonin-containing nuclei; Connectivity; Conclusions; References; Chapter 1.4 Ultrastructure of the Serotonin Innervation in the Mammalian Central Nervous System; Introduction; 5-HT cell bodies and dendrites; 5-HT innervation of the forebrain; 5-HT innervaton of the brainstem; 5-HT innervation of the cerebellum; 5-HT innervation of the spinal cord; Concluding remarks; Acknowledgements; References. Chapter 1.5 Classification and Signaling Characteristics of 5-HT ReceptorsIntroduction; Historical perspective of 5-HT receptor classification: a ping-pong game between pharmacology and molecular biology; Genomic, post-genomic characteristics of 5-HT receptors; G protein-mediated signaling; Non-G-protein dependent signaling; Constitutive activity; Agonist-directed signaling; Toward the notion of a 5-HT receptor complex; 5-HT[sub(3)] receptor signaling; References; Chapter 1.6 Distribution of 5-HT Receptors in the Central Nervous System; Introduction; 5-HT[sub(1A)] receptors. 5-HT[sub(1B)] receptors5-HT[sub(1D)] receptors; 5-ht[sub(1E)] receptors; 5-HT[sub(1F)] receptors; 5-HT[sub(2A)] receptors; 5-HT[sub(2B)] receptors; 5-HT[sub(2C)] receptors; 5-HT[sub(3)] receptors; 5-HT[sub(4)] receptors; 5-ht[sub(5a)] receptors; 5-HT[sub(6)] receptors; 5-HT[sub(7)] receptors; Conclusion; References; Chapter 1.7 Measuring Serotonin Activity in vivo in the Brains of Animals and Humans; Introduction; Measurement of serotonin release (efflux) in vivo; Measurement of receptors and transporters in vivo; Tryptophan depletion and the measurement of serotonin function. Neuroendocrine markers and serotonergic functionMeasurement of neuronal activity
neural pathways; Conclusions; Acknowledgements; References; Section 2: The Neurophysiology of Serotonin; Chapter 2.1. Activity of Brain Serotonergic Neurons in Relation to Physiology and Behavior; Introduction; Basic neuronal characteristics; Sleep-wake-arousal cycle; Response to stressors; Autonomic function; Motor activity; Fatigue; Discussion; Acknowledgement; References; Chapter 2.2. Electrophysiology of Serotonin Receptors; Introduction; 5-HT[sub(1A)] receptors; 5-HT[sub(1B)] receptors
5-HT[sub(1D)] receptors