Combinatorial Chemistry and Technology: Principles, Methods and ApplicationsStanislav Miertus, Giorgio Fassina CRC Press, 1 iul. 1999 - 448 pagini "Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules." |
Cuprins
Combinatorial Chemistry and Combinatorial Technologies Principles and Applications | xi |
Synthesis and Characterization of Peptide Libraries | 5 |
SolidPhase Synthesis of Organic Libraries | 21 |
Resins Linkers and Reactions for Solid Phase Synthesis of Organic Libraries | 33 |
SolutionPhase Combinatorial Libraries of Small Organic Molecules | 51 |
Direct Deconvolution Techniques for Pool Libraries of Small Organic Molecules | 89 |
Encoding Techniques for Pool Libraries of Small Organic Molecules | 125 |
Analytical Characterization of Synthetic Organic Libraries | 167 |
Computational Aspects of Combinatorial Chemistry | 249 |
Biological Libraries | 273 |
Peptide Display Libraries Design and Construction | 299 |
Making and Selecting from Phage Antibody Libraries | 321 |
Biopanning | 363 |
Globular Oligonucleotide Screening via the SELEX Process Aptamers as HighAffinity HighSpecificity Compounds for Drug Development and Prote... | 387 |
Economics of Combinatorial Chemistry and Combinatorial Technologies | 401 |
Index | 419 |
Automation in Combinatorial Chemistry | 203 |
Key Ingredients for Efficient High Throughput Screening | 231 |
Alte ediții - Afișează-le pe toate
Combinatorial Chemistry and Technology: Principles, Methods and Applications Stanislav Miertus,Giorgio Fassina Nu există previzualizare disponibilă - 1999 |
Termeni și expresii frecvente
Acad Sci USA active affinity amines amino acids analysis analytical antigen applications approach aptamer assay automated bacteria bacteriophage beads binding Biol biological Biopanning brary building blocks cells characterization Chem Chem Soc chemical cleavage clones coding coli combinatorial chemistry combinatorial libraries combinatorial synthesis combinatorial technologies components compounds databases deconvolution descriptors drug discovery elution encoding enzyme epitopes example Figure fragments functional genes HPLC identified inhibitors iterative deconvolution KD Janda large numbers library synthesis ligands linker method mixtures molecules monomer monomer set mutation Natl Acad Sci oligonucleotide organic organic synthesis parallel synthesis peptide libraries phage antibody phage display phage display library phagemid Proc Natl Acad protein purification random peptide reaction vessels reagents receptor resin robotic samples scFv screening selection SELEX sequences solid support solid-phase synthesis soluble solution solution-phase specific step strategies structure sublibraries subset surface tags target techniques tested Tetrahedron Lett tion vector
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