The Lac Operon: A Short History of a Genetic ParadigmWalter de Gruyter, 1996 - 207 pagini This book describes the history and present knowledge of a paradigmatic system, the lac operon of E. coli. The first part of the book presents the history of the operon and various schools of thought regarding genetic control in general. The second part presents a number of false interpretations and misconceptions and demonstrates how easily a scientist may deceive himself. The third and last part thoroughly covers the current state of knowledge of the lac operon including the importance of the auxiliary operators and discussions of several X-ray structures, one of which was published shortly before this book went into press. A unique combination of personal anecdotes and present-day science makes this book appealing to students, postdocs, active and retired researchers alike. |
Alte ediții - Afișează-le pe toate
The lac Operon: A Short History of a Genetic Paradigm Benno Müller-Hill Previzualizare limitată - 2011 |
Termeni și expresii frecvente
Acad amino acid analysis B-galactosidase bacteria base pairs Beckwith Biol cAMP CAP protein Chem cloning codon Cold Spring Harbor coli cell complex Crystal structure deletions dimer DNA binding DNA sequence domain Ebright EMBO enzyme Escherichia coli experiment fold fragment function galactose galactoside genetic glucose helices HTH motif inducer interaction IPTG isolated J.Biol J.Mol Jacob Jacques Monod lac operator lac operon Lac permease lac promoter Lac repressor Lac repressor binds lac repressor headpiece lac repressor-operator lac system lacl lactose lactose operon lacZ gene loop Matthews Maxam Miller minor groove molecular biology molecules Monod mutants N-terminal Natl Nucl.Acids Res operator DNA paper Pasteur peptide phage position presence pressor Proc Ptashne receptor recognition helix region repression residues RNA polymerase Science sequence of Lac specific Steitz substrate subunit synthesis tetramer tetrameric Lac repressor transacetylase vitro vivo Walter Gilbert Wilcken-Bergmann wild type wildtype yeast