period he remained away from his family, though wanting very much to be with them. During this time he underwent some hypnotic and psychoanalytic treatment with negative results, and there are recorded three ineffectual attempts at suicide. With this subject the regular experiment was performed four times; on August 19 and 27, and December 23, 1907, and February 24, 1908.

The first two experiments were performed within about a month after the patient's admission. In the first experiment the subject

seemed to co-operate willingly, although expressing many depressive ideas, especially toward the close of the experiment, when he talked more. This experiment was made in the afternoon, while the experiment of a week later was made in the morning, and at this time he was more depressed. The curves in these experiments are as shown in Fig. 4.

These records, especially those in the second experiment, are as marked illustrations of intraserial warming up and reversal as the writer has observed. The first interval is always the worst, while in only one of the records is the final interval surpassed by an earlier one. For the period used, therefore, the

fatigue-curves are almost the reverse of the normal. The transference" phenomenon is, however, altogether absent; if anything, it is the preceding hand which is more favored.

During the time up to the next experiment the patient was clinically noted to improve somewhat, and he began to occupy

himself with various intellectual pursuits that interested him. A physician's note of his condition of January 1, 1908, reads in part: "The patient eats and sleeps well and takes a moderate amount of exercise, though a great deal of his time is spent in his room where he reads and writes. He is always cheerful and agreeable. He was granted parole of the grounds on October 23. Since then he has taken several trips to Cambridge with

his friends. These he invariably enjoys." A nurse's note made the day before the third experiment speaks of him as "doing well, seems more cheerful." We have apparently to do, therefore, with some progressive improvement in the patient's condition which may be compared with the difference in response to the test.

The curves in the third experiment, December 23, 1907, are as shown in Fig. 5.

The most striking feature of these curves is that the curves of the two hands are of a totally opposite type. The right hand, which precedes, shows a typically reversed curve, while the left hand, which follows, shows a curve much more approximating the normal, with reversal only in the second interval. It is to be noted also that while the left hand was inferior to the right in both previous experiments, it is now markedly superior to it. These phenomena indicate a considerable progressive change in the fatigability of the two hands throughout the experiment. The character of this change is best shown in the curve of the f itself, given below the rate curves for the two hands. It will be observed that regardless of the hand used, the f shows a progressive decrease throughout the two records. That is, the further the "resistances" of the depression are overcome by the work in hand, the more do the characteristics of the retarded work-curve disappear, and the more does the work-curve approach a normal character, with f's below 1.00. In the first two experiments the patient responded to these warming-up influences only within a single series, thus affording in both hands fairly typical reversed curves; but now, after a certain interval marked clinically by improvement in condition, the warming-up influence extends not only from series to series, but progressively throughout the records. An examination of the individual fatigue-curves shows how the earlier ones are typically reversed, and how this condition gradually changes over into the normal. The first curve of the experiment, made with the right hand, runs 25-27-2728-29-29, f 1.12, a typically reversed curve; the last curve of the experiment, made with the left hand, runs 30-28-28-2726-26, f .90, a typical normal curve. The apparent superiority of the left hand to the right is presumably a real "transference phenomenon.