Oncogenes and Cancer: Proceedings of the 17th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1986Stuart A. Aaronson VSP, 1987 - 309 pagini Discoveries that a small subset of cellular genes --- proto-oncogenes --- are frequent targets of carinogenic insults or chance that convert them to oncogenes have opened new areas of approach to understanding and eventually controlling the events leading to cancer. New technology has made it possible not only to identify genes involved in the etiology of cancer, but to dissect their molecular composition. This symposium brought together scientists from areas of carcinogenesis and molecular biology to review the state-of-the-art in this field. The papers presented in this proceedings volume can be grouped into four broad areas: the mechanisms of onc gene activation and associations of onc genes with tumours, the mechanisms of onc gene action, the physiology of proto-onc genes, and the discovery and characterization of new onc genes. |
Cuprins
The Pathobiology of Protooncogenes J M Bishop | 3 |
Nonreceptor Type Proteintyrosine Kinases Closely Related to src and | 11 |
Two New Retroviral onc Genes sea and jun T J Bos H Beug | 23 |
The int1 Protooncogene H Varmus A Brown J Papkoff and G Shackleford | 31 |
Involvement of ras Oncogenes in the Initiation of Carcinogeninduced Tumors | 43 |
Transformation by raf and myc Oncogenes U R Rapp J L Cleveland | 55 |
Activation of Rat and Human craf1 by Rearrangement | 75 |
Role of Genes for Normal Growth Factors in Human Malignancy | 95 |
Altered Expression of Epidermal Growth Factor Receptors in Human Bladder | 183 |
Analysis of Structure and Activation of Some Receptortype Tyrosine Kinase | 195 |
Expression of the cerbB2 Gene Encoding a Growth Factor Receptor | 203 |
Requirements for Transformation by the fms Oncogene Product CSF1 Recep | 211 |
The Human met Oncogene Is a Member of the Tyrosine Kinase Family | 221 |
Transformation by p60sre with Altered Nterminal Sequences | 233 |
Investigations of the Expression of the Cellular src Gene Product | 241 |
Exploring the Function of RAS Oncogenes by Studying the Yeast Saccharomyces | 253 |
Chromosomal Deletion Gene Amplification Alternative Processing and Auto | 109 |
A Novel Transforming Gene hst from Human Stomach Cancers and a Non | 123 |
A Novel Oncogene from a Human Hepatocellular Carcinoma | 133 |
Involvement of the abl Oncogene in Human Chronic Myelogenous Leukemia | 143 |
Molecular Genetics of B and Tcell Neoplasia | 151 |
Chromosomal Translocations in Bcell Derived Tumors G Klein | 159 |
Detection of Genes with Potential of Suppressing Transforming Activity of | 261 |
Teratocarcinoma Derived from Mouse Zygotes after the Introduction of Acti | 269 |
An Inducible Gene I M Verma R L Mitchell | 279 |
Analysis of cmyc Protein Degradation | 291 |
Author Index | 303 |
Termeni și expresii frecvente
3T3 cells Acad allele amino acid amino acid sequence amplification analysis antibody B-cell Biol c-fms c-fos c-Ha-ras c-myc c-myc protein c-raf c-src cancer cell carcinoma cDNA cell lines cell lung cellular chromosomal translocations clones coding containing detected differentiation EcoRI EGF receptor encoding epidermal growth factor exon expression fibroblasts fragment function gene product genetic genome growth factor receptor homology human tumors hybridization induced isolated kinase activity lca DNA leukemia levels locus lung cancer lymphoma malignant mammary membrane mice molecular mouse mRNA murine mutations Natl NIH 3T3 NIH/3T3 cells normal nucleotide nucleotide sequence onc gene oncogene peptide phosphorylation probe Proc protein kinase proto-oncogene Rapp RAS proteins rearrangement recombination region retinoblastoma retroviral sarcoma virus SCLC Southern blot specific src gene structure TGFa tion tissue transcript transfection transforming activity transforming gene tumor cells tyrosine kinase v-fms v-myc v-raf viral viruses vitro yeast