Oncogenes and Cancer: Proceedings of the 17th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1986

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Stuart A. Aaronson
VSP, 1987 - 309 pagini
Discoveries that a small subset of cellular genes --- proto-oncogenes --- are frequent targets of carinogenic insults or chance that convert them to oncogenes have opened new areas of approach to understanding and eventually controlling the events leading to cancer. New technology has made it possible not only to identify genes involved in the etiology of cancer, but to dissect their molecular composition. This symposium brought together scientists from areas of carcinogenesis and molecular biology to review the state-of-the-art in this field. The papers presented in this proceedings volume can be grouped into four broad areas: the mechanisms of onc gene activation and associations of onc genes with tumours, the mechanisms of onc gene action, the physiology of proto-onc genes, and the discovery and characterization of new onc genes.
 

Cuprins

The Pathobiology of Protooncogenes J M Bishop
3
Nonreceptor Type Proteintyrosine Kinases Closely Related to src and
11
Two New Retroviral onc Genes sea and jun T J Bos H Beug
23
The int1 Protooncogene H Varmus A Brown J Papkoff and G Shackleford
31
Involvement of ras Oncogenes in the Initiation of Carcinogeninduced Tumors
43
Transformation by raf and myc Oncogenes U R Rapp J L Cleveland
55
Activation of Rat and Human craf1 by Rearrangement
75
Role of Genes for Normal Growth Factors in Human Malignancy
95
Altered Expression of Epidermal Growth Factor Receptors in Human Bladder
183
Analysis of Structure and Activation of Some Receptortype Tyrosine Kinase
195
Expression of the cerbB2 Gene Encoding a Growth Factor Receptor
203
Requirements for Transformation by the fms Oncogene Product CSF1 Recep
211
The Human met Oncogene Is a Member of the Tyrosine Kinase Family
221
Transformation by p60sre with Altered Nterminal Sequences
233
Investigations of the Expression of the Cellular src Gene Product
241
Exploring the Function of RAS Oncogenes by Studying the Yeast Saccharomyces
253

Chromosomal Deletion Gene Amplification Alternative Processing and Auto
109
A Novel Transforming Gene hst from Human Stomach Cancers and a Non
123
A Novel Oncogene from a Human Hepatocellular Carcinoma
133
Involvement of the abl Oncogene in Human Chronic Myelogenous Leukemia
143
Molecular Genetics of B and Tcell Neoplasia
151
Chromosomal Translocations in Bcell Derived Tumors G Klein
159
Detection of Genes with Potential of Suppressing Transforming Activity of
261
Teratocarcinoma Derived from Mouse Zygotes after the Introduction of Acti
269
An Inducible Gene I M Verma R L Mitchell
279
Analysis of cmyc Protein Degradation
291
Author Index
303
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