VIII. STUDIES IN HEREDITY WITH EXAMPLES. William C. Sandy... 587 XVI. ANATOMICAL FINDINGS IN SENILE DEMENTIA. E. E. Southard 673 Honor to Dr. Carlos F. MacDonald.—A Unique Experience with Pellagra.-The Munich Clinic and Dementia Præcox. -Summer School for Attendants in Institutions for the In- sane in Illinois.-The Journal of Educational Psychology.— American Medico-Psychological Association.-Erratum. .709-721 Dr. Walter Robarts Gillette.-Dr. Oliver M. Dewing.─Dr. H. A. Tobey.-Dr. H. E. Buchan.-Dr. Charles E. Hickey.722-727 Serum Diagnosis of Syphilis and the Butyric Acid Test for Syphilis. By Hideyo Noguchi, M. D., M. Sc. (Philadelphia: J. B. Lippincott Co., 1910.)—Thirty-eighth Annual Report of the Board of Commissioners of Public Charities of Pennsyl- vania. (Harrisburg, Pa.: State Printer, 1909.)—Forty-fifth Annual Report of the Trustees of the Boston City Hospital. (City of Boston, Printing Department, 1909.)... ... ... .... ...747-748 A Study of Errors of Diagnosis in General Paresis.—Blut- druckmessungen in Geisteskranken.-Ricerche di sfigmoma- nometria e sfigmografia nei dementi precoci.-Come si com- portano, in relazione alle alternative di attività et di riposo, le misure sfigmomanometriche e dinamometriche nei malati di mente applicati at lavoro.... AMERICAN JOURNAL OF INSANITY MOTOR RETARDATION AS A MANIC-DEPRESSIVE SYMPTOM. BY FREDERIC LYMAN WELLS, PH. D., Assistant in Pathological Psychology in the McLean Hospital, Waverley, Mass. CONTENTS. 1. The Experimental Criterion of Retardation.. 2. Clinical Histories and Experimental Results. I. THE EXPERIMENTAL CRITERION OF RETARDATION. PAGE I 13 46 Our reaction to a given situation is determined by the lines of In a fundamental retardation we have an agency or number of agencies, presumably of toxic origin, which tend to increase the difficulty with which certain nervous impulses, consequently certain psychic functions, can proceed. The actual study of cases shows us that the symptom of retardation may involve the various mental functions largely independently of one another. When its manifestations occur mainly in the higher, associative processes of the mind, we speak of it as a "difficulty in thinking" or "thinking disorder "; we may also see its phenomena confined with some definiteness to the motor side; and as has been elsewhere suggested, those manic-depressive states which show an emotional condition of apparent apathy in contradistinction to depression are the manifestation of this same symptom in the affective sphere. In like manner we may find these phenomena even more restricted within the categories mentioned. It is obvious, however, that in merely speaking of a greater difficulty" of the nervous processes, we do not tell the whole story of the effect of this difficulty upon the resulting movements, which are, of course, our ultimate criteria of the symptom. The response may be merely delayed, without seeming to be otherwise affected. More often, however, there is coupled with this delay a certain weakening of its force and effectiveness. On the other hand, the response may be long delayed and then come with explosive force, as though the patient had been gradually accumulating sufficient energy to burst through the retardation. Occasionally the response fails entirely, apparently from not being strong enough to break through; this is apt to be the case with indifferent situations. Under great stresses, however, a marked retardation may be entirely swept away, indicating a considerable reserve strength of the voluntary impulse, just as our muscles seldom if ever put forth under voluntary stimulation the effort of which they are physiologically capable. Clinically, we judge of a patient's retardation through the general character of his behavior, by the quickness with which he seems to think or speak or move. Experimentally, we make use of the innumerable tests put forward as measures of mental time. So long as we deal only with the presence or absence of retardation in general, the precise mental function that we select to measure is probably of secondary importance to the accuracy of the experimental method itself. Most such experiments, however, would afford very little information about the character of the retardation, whether concerned with the lower, motor, or higher, associative processes. A purely intellectual retardation we cannot measure directly by any psychological methods at present known, for we always require some form of motor response in addition to the intellectual or associative process. We may first turn attention therefore to the functions which are more primarily motor, attempting to make our measure of retardation, so far as possible, independent of the higher mental processes. To experimentally isolate mental retardation from motor retardation is no easy task. Almost every experiment in the time relations of voluntary movement involves a conscious process of greater or less complexity, followed by a motor response. While this is not absolutely true (as in simple reaction time in late practice) it is essentially so in the situations with which we have to deal clinically. For rough and ready purposes, some idea can be gained from the comparative degrees of retardation in responses involving different degrees of purely mental effort. Thus if a subject could calculate but slowly, and yet could respond quickly to commands, the indication would be that the retardation was mainly in the nature of a thinking disorder. On the other hand, the more the simple and complex responses were equal in slowness, the greater the likelihood of a retardation principally in the lower, motor centres. The presence of a certain amount of ordinary motor activity does not prove the absence of a motor retardation. The essential point here would be whether the reactive movements are quick or slow, and this does not appear in the ordinary observation of a patient's behavior. The phenomena which seem to be associated with motor retardation in these experiments have appeared most strikingly in cases in which little if any retardation would have been evident to ordinary clinical examination. But, as has been said, the time of reaction in most psychological experiments is an unsatisfactory measure, since there is not sufficient differentiation between the mental and motor aspects of the symptom. Even such a measure as simple reaction to sound is, at all ordinary stages of practice, seriously vitiated by this difficulty in interpretation. Obviously, the simpler and more in |