tures. The spinal fluid contains more lymphocytes and protein than is considered normal; the Noguchi test was negative. The Wasserman reaction was positive with both blood serum and spinal fluid. The blood cultures showed no growth. In this case the nitrogen is not low in amount and there is less deviation from the normal in this patient than in any of the others. This is to be noted not only in the absolute, but also in the relative amounts of the different urinary constituents. In connection with the results here given it is to be remembered that in this patient the disease has been evident for only six months, whereas in no one of the remaining patients was the duration less than eighteen months and in most of them much more.

E. J. D.-Case No. 1786. Table IV. Male, age 56.6. Positive luetic infection. Mild seizures have occurred since the onset every few weeks. Until a year ago the patient was not treated in a hospital. General physical condition at the present time is good. Pupils are irregular and unequal and there is no reaction to light. Nearly all deep reflexes are increased and there is a marked tremor. Insight lacking and memory poor. Duration, about three years; diagnosis, paresis. Hyoscin-morphin given on the 4th. Lymphocytes and protein are increased in the spinal fluid; the Noguchi test was positive. The Wasserman reaction was negative with the spinal fluid and positive with the blood serum. Blood cultures sterile. Although this patient weighs over twenty kilos more than the preceding one, the absolute amounts of the different urinary bodies are in most cases slightly less. In the case of E. J. D. there is considerable adipose tissue, whereas H. S. W. is much emaciated.

R. B. S.-Case No. 1787. Table V. Male, age 63.6; no doubt of syphilitic infection. The onset was marked by failing memory, irritability and later a hypomaniacal state, with ideas of persecution. At the present his physical condition is poor and there has been a decided falling off in weight. Pupils do not react to light; there is a tremor of the tongue and hands and the knee jerks are exaggerated. He is disoriented as to time, place and person. Hallucinations and delusions are very active and at times his excitement exhibits itself in actual violence. Duration, about 1.5 year; diagnosis, paresis. There was an increase in the number of lymphocytes and in the amount of protein in the spinal fluid and the Noguchi test was positive. The Wasserman reaction was positive with both the spinal fluid and blood serum. Blood cultures were sterile. Hyoscin-morphin given May 18 and 19. There does not seem to be any particular change in the metabolism, as shown by the urinary analysis, other than that the total amounts excreted are somewhat low in general and that the same points as have been indicated in the other cases are present here also.