High Throughput Screening for Novel Anti-InflammatoriesMichael Kahn Springer Science & Business Media, 1 mai 2000 - 258 pagini Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent the state of the art regarding the integration of combinatorial chemistry and HTS in connection with anti-inflammatory targets. Obviously, there is much work to be done beyond what is described in this text, nevertheless, it should set the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating inflammatory diseases. |
Cuprins
Applications to combinatorial libraries | iii |
Proteasome inhibitors | 9 |
Opportunities and progress | 25 |
Elastase inhibitors | 39 |
A high throughput assay for the TNF converting enzyme | 77 |
Tryptase inhibitors | 91 |
Selectin antagonists | 113 |
Cell adhesion integrins as pharmaceutical targets | 135 |
Inhibitors of the MAPK pathway | 155 |
Inhibition of NFkB | 183 |
IL1 antagonist discovery | 195 |
Phosphodiesterase inhibitors for respiratory diseases | 213 |
Index | 245 |
Alte ediții - Afișează-le pe toate
High Throughput Screening for Novel Anti-Inflammatories Michael Kahn Nu există previzualizare disponibilă - 2012 |
High Throughput Screening for Novel Anti-Inflammatories Michael Kahn Nu există previzualizare disponibilă - 2014 |
Termeni și expresii frecvente
Acad Sci USA affinity airway amino acid antagonist anti-inflammatory apoptosis arthritis assay asthma binding Biochem Biol Chem biological Bioorg Med Chem caspase-1 caspases catalytic cell adhesion Chem Chem Lett Clin clinical cloning combinatorial complex compounds crystal structure cyclic AMP cytokine domain drug discovery E-selectin effects elastase inhibitors eosinophil function gene H₂C human leukocyte elastase human mast cell human neutrophil identified Immunol inflammation inhibition inhibitors of human integrin interaction interleukin-1 ketones libraries ligands lung MAPK mast cell mast cell tryptase matrix metalloproteinase mediated mitogen-activated protein kinase molecular Natl Acad Sci neutrophil elastase novel pathway PDE3 PDE4 inhibitors peptide Pharmaceuticals Pharmacol phosphodiesterase inhibitors potent Proc Natl Acad protease proteasome protein kinase proteinase receptor residues Respir role rolipram selectin selective sequence serine signal sLex small molecule specific substrate subunits synthesis TACE targets theophylline therapeutic tion tissue tryptase tryptase inhibitors vitro vivo