Handbook of the Behavioral Neurobiology of Serotonin
Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft.
The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour.
This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise.
The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders.
Ce spun oamenii - Scrie o recenzie
Nu am găsit nicio recenzie în locurile obișnuite.
Alte ediții - Afișează-le pe toate
5-HT neurons 5-HT system 5-HT1A receptor 5-hydroxytryptamine activity afferents Aghajanian agonist amino acid amygdala animal antidepressant anxiety autoreceptors axons Azmitia Behav binding Biochem Biol Brain Res brainstem central cloning cocaine Comp cortical decrease dendritic depression Descarries disorder dopamine dorsal raphe nucleus drugs effects enzyme expression extracellular fenfluramine fluoxetine forebrain function GABA GABAergic genetic hippocampus human immunoreactive increased induced inhibition innervation interactions interneurons involved lesions levels MDMA median raphe mediated mice microdialysis midbrain modulation monoamine oxidase mPFC mRNA Neurochem neurons Neuropsychopharmacology Neurosci neurotransmitter pathways Pharmacol pharmacological Physiol polymorphism postsynaptic prefrontal cortex projections protein Psychiatry Psychopharmacology pyramidal cells raphe nucleus rat brain recep receptor antagonist receptor gene receptor subtypes reduced region regulation release response rodents role sero serotonergic serotonergic neurons serotonergic system serotonin receptors serotonin transporter spinal SSRIs stimulation stress studies synaptic terminals theta tion tonin treatment tryptophan depletion tryptophan hydroxylase varicosities vivo