Immunological Recognition of Peptides in Medicine and BiologyCRC Press, 19 iul. 1995 - 320 pagini Immunological Recognition of Peptides in Medicine and Biology gives a state-of-the-art overview on the use of peptides and peptide-ligand interactions, and the critical role they play in recognition patterns for the regulation of various biological functions. A wide range of applications are discussed, including some experimental preclinical ones such as epitope mapping, peptide libraries, and production of amino acid-specific antibodies and their therapeutic use in oncology and infectious disease vaccines. Each chapter also includes step-by-step protocols to aid in actual experiments. Several alternative techniques and strategies are discussed by different authors offering the reader an opportunity to select the most favorable application for a specific biological problem. |
Cuprins
Modalities of Functional Peptide Characterization | 1 |
Immunological Recognition of Peptides | 13 |
PEPSCAN to Determine T and B Cell Epitopes | 15 |
Epitope Mapping Studies with Paper DiscBound Peptides | 33 |
Construction and Utilization of Peptide Libraries Displayed by Filamentous | 43 |
The Analysis of Peptide Binding to MHC and of MHC Specificity | 61 |
Promiscuity and Specificity of T Cell Epitopes | 79 |
Processing of Proteins in the MHC Class II Pathway | 89 |
Structure Function Relations and Synthesis of Special Derivatized Peptides | 125 |
Analysis of Peptide and Protein Structure | 133 |
Synthesis Analysis and Conformation of Glycopeptides and Phosphopeptides | 147 |
Lipopeptides as Adjuvants and Integrated Adjuvanticity | 159 |
Preclinical and Experimental Clinical Applications of Peptides | 245 |
Cytotoxic T Lymphocyte EpitopeBased Peptide Vaccines | 255 |
Peptide Applications in Autoimmune Disease Research | 269 |
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Termeni și expresii frecvente
Acad Sci USA activity adjuvant affinity amino acid amino acid sequence antibody binding antibody response antibody-binding peptide antigen presentation antigen processing antigenic determinant assay binding peptides Biochem Biol buffer Buus carrier cathepsin cathepsin D cell determinant cell epitopes Chem class II molecules clones conformational conjugates coupling cytotoxic denatured different peptides ELISA eluted endocytic endosomes enzyme Fel d fragments gene Geysen glycopeptides helper T cell Houghten identified immune response immunogenic Immunol immunological Incubate induced infected inhibited inhibitor interaction large numbers ligands lipopeptide lymphocytes macrophages major histocompatibility complex method MHC class MHC class II MHC molecules mice monoclonal antibodies motif native protein Natl Acad Sci PEPSCAN peptide binding peptide libraries peptide mixtures peptide synthesis peptide-MHC phage position Proc Natl Acad protease protein protein antigen proteolysis pVIII receptor recognized residues selection Sette solid-phase solid-phase synthesis SPCL specific structure surface synthetic peptides tion vaccine viral virus vivo
Pasaje populare
Pagina x - Geysen, HM, Meloen, RH, and Barteling, SJ (1984) Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.