Combined Effects of Drugs and Toxic Agents: Modern Evaluation in Theory and PracticeSpringer Vienna, 16 mar. 1993 - 167 pagini Scientists struggling with the pharmaco- and toxicodynamic interactions of drugs and chemicals will find this book a valuable reference to the relevant theoretical background of this complex field and an indispensible guide to practical, analytical procedures for evaluation of experimental data. A new, straightforward mechanistically based analysis of observed combination effects is backed up by numerous examples as well as by computer-assisted plotting and curve fitting – using popular graphical software systems. The reader thus can gain not only a modern understanding of this complex area but proceed directly to the evaluation of his own dose-response experiments with respect to independent actions, and additive interactions, where appropriate. The meanings of terms and acronyms in the literature, most of them used in this book also, are elucidated by a comprehensive glossary. This book represents a modern, theoretical and practical guide for all scientists dealing with this controversial and complex area of the action and interaction of drugs and chemicals. |
Cuprins
Principle considerations of drug actions and interactions | 1 |
Concepts and models of interactions additivity and independence | 15 |
Synergismpotentiation and antagonism phenomena and mechanisms | 39 |
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Combined Effects of Drugs and Toxic Agents: Modern Evaluation in Theory and ... Gerald Pöch Previzualizare limitată - 2012 |
Termeni și expresii frecvente
additive and independent additive combinations additive DRC ADP-ribose ALLFIT antagonistic approach Berenbaum binding calculation of independent Chou and Talalay cimetidine cisplatin combined effects combined-effect graph comparison of observed comparison with additivity comparison with independent competitive interaction compounds correspond different sites dose-additive dose-additive combinations dose-response relationship dose-response studies drugs effect-additive effective dose effects in combination Emax enhanced equieffective doses ethanol etoposide examples exhibit expected for independent experimental expressed fects fixed dose flat DRC flurazepam fraction frequency greater than independent Hence independent action independent combinations independent DRCs independent effects independent interactions indicate individual effects inhibition inhibitors isobolograms LINDANE malathion mechanisms MIDAZOLAM mixtures molecular mutually nonexclusive nicorandil overadditive parathion partial agonist phenomenon Pirenzepine Pöch potentiation quantitative receptor respect response salbutamol schematically shown in Fig shows slope values steep DRCs steepness of DRCs synergism tamoxifen theophylline theoretical DRCs time-course studies tion TOBRAMYCIN total effects toxic underadditive combinations verapamil