Drug Discovery HandbookShayne Cox Gad John Wiley & Sons, 24 iun. 2005 - 1496 pagini The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including:
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2 Cancer Cell Proteomics Using Molecular Aptamers | 73 |
3 Molecular Similarity Methods and QSAR Models as Tools for Virtual Screening | 87 |
4 Systems Biology Applications in Drug Discovery | 123 |
5 HighThroughput Flow Cytometry | 185 |
6 Combining NMR Spectral Information with Associated Structural Features to Form Computationally Nonintensive Rugged and Objective Models o... | 227 |
7 Using Microsoft Excel as a Laboratory Data Management Tool | 287 |
8 Age of Regulation | 337 |
9 Simultaneous Screening of Multiple Cell Lines Using the CellCard System | 353 |
17 Design and Pharmaceutical Applications of Prodrugs | 733 |
18 GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders | 797 |
19 Cardiac Sarcolemmal ATPSensitive Potassium Channel Antagonists Novel IschemiaSelective Antiarrhythmic Agents | 909 |
20 Factors Influencing the Efficacy of MediatorSpecific AntiInflammatory Glucocorticoid and Anticoagulant Therapies for Sepsis | 937 |
| 961 | |
22 Herbal Medicines and Animal Models of Gastrointestinal Diseases | 1013 |
23 Endocrine and Metabolic Agents | 1037 |
24 Respiratory Viruses | 1105 |
10 Protein Xray Crystallography in Drug Discovery | 373 |
11 Biological and Chemistry Assays Available During Drug Discovery and Developability Assessment | 457 |
12 Strategies and Methods in Monitoring and Targeting ProteinProtein Interactions | 483 |
13 HighThroughput Screening Evolution of Technology and Methods | 559 |
14 MetalEnhanced Fluorescence Application to HighThroughput Screening and Drug Discovery | 603 |
15 Methods for the Design and Analysis of ReplicateExperiment Studies to Establish Assay Reproducibility and the Equivalence of Two Potency Ass... | 667 |
16 Coupled Luminescent Methods in Drug Discovery 3Min Assays for Cytotoxicity and Phosphatase Activity | 689 |
25 Strategies in the Design of Antiviral Drugs | 1135 |
26 Protein Kinase Inhibitors in Drug Discovery | 1191 |
27 RNABased Therapies | 1259 |
28 Novel Imaging Agents for Molecular MR Imaging of Cancer | 1309 |
29 Targets and Approches for Cancer Drug Discovery | 1343 |
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Termeni și expresii frecvente
affinity agents agonist amino acid AMPA receptor analysis antagonists approach aptamer arrestin assay atoms ATP-sensitive potassium channel benzodiazepine binding Biochem Biol biological activity cancer cDNA cell Chem chemical shifts clinical complex compounds CoSCoSA model COSY crystal crystallographic database descriptors detection diffraction data drug discovery effects enzyme esters evaluation example expression factor Figure fluorescence fluorophores function G protein GABA GABAA receptor GAL4 gene genome glutamate receptor GPCR high-throughput high-throughput screening human identified increase inhibition inhibitors kinase libraries ligand membrane metabolism metabotropic metabotropic glutamate receptor methods mGluRs microarrays modules molecular molecules natural products NMDA novel pathways peptide percent Pharmacol pharmacological pharmacophore plate potassium channel potential predicted prodrugs protein protein–protein interactions proteome QSAR sample screening selective sepsis signal silver solubility specific spectra structure studies substrate subunit synthesis target therapeutic tion tumor two-hybrid system vitro X-ray yeast