Toxicological Profile for DDT, DDE, and DDDAgency for Toxic Substances and Disease Registry, 1989 - 143 pagini |
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Termeni și expresii frecvente
absorption ACGIH administration airborne arsenic animals arsanilic acid arsenic acid arsenic exposure arsenic levels arsenic toxicity arsenic trioxide arsenic-induced arsenobetaine arsine blood Buchet Calcium arsenate carcinogenicity chemical concentrations of arsenic copper smelter dermal detected diet dose-response relationship drinking water effects of arsenic Environ Health Environmental Protection Agency EPA Environmental Protection epidemiological estimated exposure levels exposure to arsenic forms of arsenic gastrointestinal hamsters health effects human exposure hydride hyperkeratoses increased ingestion inhalation exposure inorganic arsenic compounds intratracheal lethality levels of arsenic levels of exposure levels of significant liver lung cancer Marafante metabolism methylation mg/kg mg/kg/day mg/L mg/m³ mice ND ND ND neuropathy NIOSH oral doses oral exposure organic pesticide Phenylarsonates population rats reported roxarsone skin cancer smelter smelter workers sodium arsenite soil soluble studies Substances teratogenic tissues toxicokinetics Toxicol toxicological trivalent unit risk urinary arsenic urinary excretion urine Vahter water containing µg/day µg/L µg/m³
Pasaje populare
Pagina 5 - The examination, summary, and interpretation of available toxicologic information and epidemiologic evaluations on a hazardous substance to ascertain the levels of significant human exposure for the substance and the associated acute, subacute, and chronic health effects; (B) A determination of whether adequate information on the health effects of each substance is available or in the process of development to determine levels of exposure that...
Pagina 25 - During the development of toxicological profiles, Minimal Risk Levels (MRLs) are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration for a given route of exposure. An MRL is...
Pagina 1 - Other pertinent literature is also presented, but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The...
Pagina 119 - The upper-bound estimate of the low-dose slope of the dose-response curve as determined by the multistage procedure. The q,* can be used to calculate an estimate of carcinogenic potency, the incremental excess cancer risk per unit of exposure (usually ug/L for water, mg/kg/day for food, and ug/m3 for air).
Pagina 6 - ... describes, in nontechnical language, a substance's relevant toxicological properties. Following the public health statement is information concerning levels of significant human exposure and, where known, significant health effects. The adequacy of information to determine a substance's health effects is described in a health effects summary. Data needs that are of significance to protection of public health are identified by ATSDR and EPA.
Pagina 121 - These experts collectively have knowledge of zinc's physical and chemical properties, toxicokinetics, key health end points, mechanisms of action, human and animal exposure, and quantification of risk to humans. All reviewers were selected in conformity with the conditions for peer review specified in Section 104(I)(13) of the Comprehensive Environmental Response, Compensation, and Liability Act, as amended. Scientists from the Agency for Toxic Substances and Disease Registry (ATSDR) have reviewed...
Pagina 117 - The occurrence of adverse effects on the developing organism that may result from exposure to a chemical prior to conception (either parent), during prenatal development, or postnatally to the time of sexual maturation.
Pagina 5 - October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744); November 17, 1997 (62 FR 61332); and October 21, 1999 (64 FR 56792).
Pagina 119 - RfD is operationally derived from the no-observed-adverse-effect level (NOAEL-from animal and human studies) by a consistent application of uncertainty factors that reflect various types of data used to estimate RfDs and an additional modifying factor, which is based on a professional judgment of the entire database on the chemical. The RfDs are not applicable to nonthreshold effects such as cancer.
Pagina 4 - Mention of company name or product does not constitute endorsement by the National Institute for Occupational Safety and Health.