Human Molecular GeneticsGarland Science, 29 mar. 2018 - 808 pagini Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject. The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded. |
Cuprins
Detailed Contents | |
Nucleic Acid Structure and Gene Expression | |
The type of chemical bonding determines stability and function | |
Replication is semiconservative and semidiscontinuous | |
Most genes are expressed to make polypeptides | |
Specialized nucleotides are added to the ends of most RNA polymerase II transcripts | |
mRNA is decoded to specify polypeptides | |
The complex relationship between amino acid sequence and protein structure | |
Organization of the Human Genome | |
Model Organisms Comparative Genomics and Evolution | |
Human Gene Expression | |
Studying Gene Function in the PostGenome | |
Human Genetic Variability and Its Consequences | |
Genetic Mapping of Mendelian Characters | |
Mapping Genes Conferring Susceptibility to Complex Diseases | |
Identifying Human Disease Genes and Susceptibility Factors | |
Chromosome Structure and Function | |
Genes in Pedigrees and Populations | |
Cells and CellCell Communication | |
Principles of Development | |
Cellbased DNA Cloning and | |
Principles and Applications | |
Analyzing the Structure and Expression of Genes and Genomes | |
Cancer Genetics | |
Genetic Testing of Individuals | |
Pharmacogenetics Personalized Medicine and Population Screening Chapter 20 Genetic Manipulation of Animals for Modeling Disease and Investiga... | |
Glossary | |
Index | |