Human Molecular Genetics

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Garland Science, 29 mar. 2018 - 808 pagini

Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject.

The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.

 

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Cuprins

Model Organisms Comparative Genomics and Evolution
Human Gene Expression
Studying Gene Function in the PostGenome
Human Genetic Variability and Its Consequences
Genetic Mapping of Mendelian Characters
Mapping Genes Conferring Susceptibility to Complex Diseases
Identifying Human Disease Genes and Susceptibility Factors
Most genes are expressed to make polypeptides
Specialized nucleotides are added to the ends of most RNA polymerase II transcripts
mRNA is decoded to specify polypeptides
chemical modification of amino acids and polypeptide cleavage
Glossary
Index
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Alte ediții - Afișează-le pe toate

Human Molecular Genetics
Tom Strachan,Andrew Read
Previzualizare limitată - 2018
Human Molecular Genetics
T. Strachan,Andrew P. Read
Nu există previzualizare disponibilă - 2011

Termeni și expresii frecvente

abnormalities activity alleles amino acid amplification antibody antigens assay autosomal bacterial base pairing bind cDNA cell cycle cell division centromere chromatin chromosome cleavage codons complementary complex contains copy number cytoplasm differentiation disease DNA cloning DNA fragments DNA molecules DNA sequences DNA strands double-stranded duplication ectoderm embryo encoded enzyme epiblast eukaryotic example exons Figure fluorescence function gene expression genetic genome sequences genomic DNA germ give rise homologs host cell human genome hybridization identified inserted introns labeled linear mammalian mammals meiosis membrane Mendelian mesoderm microarray mitochondrial mitosis molecular mRNA mutation neural neurons noncoding normal nuclear nucleic acid nucleotides oligonucleotide organisms pathways pedigree phage phenotype plasmid polypeptide population primer probe produce protein protein-coding pseudogenes receptors recombinant DNA region replication result ribosomal RNA polymerase rRNA sample signaling single-stranded specific splicing stem cells structure synthesis target DNA telomere tissue transcription factors tRNA types vector vertebrate Y chromosome

Despre autor (2018)

Tom Strachan is Scientific Director of the Institute of Human Genetics and Professor of Human Molecular Genetics at Newcastle University, UK, and is a Fellow of the Academy of Medical Sciences and a Fellow of the Royal Society of Edinburgh. Tom's early research interests were in multigene family evolution and interlocus sequence exchange, notably in the HLA and 21-hydroxylase gene clusters. While pursuing the latter, he became interested in medical genetics and disorders of development. His most recent research has focused on developmental control of the vertebrate cohesion regulators Nipbl and Mau-2.

Andrew Read is Emeritus Professor of Human Genetics at the University of Manchester, UK and a Fellow of the Academy of Medical Sciences. Andrew has been particularly concerned with making the benefits of DNA technology available to people with genetic problems. He established one of the first DNA diagnostic laboratories in the UK over 20 years ago (it is now one of two National Genetics Reference Laboratories), and was founder chairman of the British Society for Human Genetics, the main professional body in this area. His own research is on the molecular pathology of various hereditary syndromes, especially hereditary hearing loss.

Drs. Strachan and Read were recipients of the European Society of Human Genetics Education Award.

Informații bibliografice

TitluHuman Molecular Genetics
AutoriTom Strachan, Andrew Read
Ediție4, ilustrată
EditorGarland Science, 2018
ISBN1136844066, 9781136844065
Lungime808 pagini
  
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