Metal Ions in Biological Systems: Volume 20: Concepts on Metal Ion Toxicity

Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Volume 20: Concepts on Metal Ion Toxicity is a logical consequence of the previous Volume 18: Circulation of Metals in the Environment. It focuses on the interrelationship between the chemistry of metal ions and their toxicologic properties. In 11 stimulating chapters by leading international experts, this authoritative volume examines the distribution of potentially hazardous metal ions, their bioinorganic chemistry, and their speciation, as well as metal ion toxicity to aquatic ecosystems, to agricultural crops, to man and animals, including nutritional aspects. Chromosome damage and carcinogenesis by metal ions are considered, and methods are summarized for the in vitro assessment of metal ion toxicity and the analysis of biological materials for toxic trace elements. With nearly 1000 references to assist further research, Concepts on Metal Ion Toxicity is an essential resource for scientists and students working in environmental chemistry; toxicology and nutrition; pharmacology; clinical chemistry; gerontology; enzymology; bioinorganic, inorganic, and coordination chemistry; and molecular biology. Book jacket.