Genetic ToxicologyAlbert P. Li CRC Press, 27 mar. 1991 - 504 pagini Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current position of some government regulatory agencies in the United States on the issues of genetic toxicology. The book will be a useful reference for students and researchers in toxicology, genetics, cancer biology, and medicine who are interested in the basic and applied principles of genetic toxicology. It will also benefit industrial toxicologists, products registration specialists, and government regulatory specialists with responsibility for the safety evaluation of industrial and environmental agents. |
Cuprins
MECHANISMS OF GENE MUTATIONS | 13 |
MECHANISMS OF INDUCTION | 41 |
GERMINAL MUTATION AND HUMAN GENETIC | 67 |
MUTATIONS AND CANCER | 93 |
ASSAYS FOR GENETIC TOXICITY | 119 |
CHEMICAL MUTAGENS | 143 |
PHYSICAL MUTAGENS | 203 |
BIOLOGICAL MUTAGENS | 257 |
ANTIMUTAGENS | 339 |
ENVIRONMENTAL MONITORING USING | 359 |
HUMAN POPULATION MONITORING | 375 |
RISK ASSESSMENT | 421 |
TSCA | 435 |
REGULATORY PERSPECTIVES FDA | 455 |
USE OF MUTAGENICITY DATA BY THE U | 473 |
Termeni și expresii frecvente
Acad acid agents alkylating alleles alterations animals Antimutagenesis antimutagenic bacterial base benzo(a)pyrene bioassay biochemical Biol biological Cancer Res Carcinogenesis carcinogens chemical mutagens Chinese hamster chromosome aberrations complex mixtures compounds cytogenetic deletions detected developed DNA adducts DNA damage DNA repair DNA sequence dose end points environmental enzymes epoxide Escherichia coli evaluation exposure frameshift frequency gene mutation genetic disease genetic effects genetic toxicology genome genotoxic genotoxicants heritable human population monitoring induced interaction involved ionizing radiation Laboratory lesions lethal liver locus lymphocytes mammalian cells measure mechanisms metabolism methyl mice microwave molecular mutagenesis mutagenic mutagenic activity mutagenicity test mutation rate Natl nucleotide occur oncogenes oxide phenotype polycyclic aromatic hydrocarbons potential Proc produced protein provirus quercetin rats replication response result retrovirus risk assessment Salmonella sample sister chromatid exchanges somatic cell specific structure studies Sugimura tion toxicity translocation tumors types typhimurium ultrasound virus vitro vivo
Referințe la această carte
Toxicology and Risk Assessment: Principles, Methods, and Applications Anna M. Fan,Louis W. Chang Nu există previzualizare disponibilă - 1995 |