Cancer: Cell Structures, Carcinogens and Genomic InstabilityLeon P. Bignold Springer Science & Business Media, 2006 - 375 pagini This volume began with an invitation from the publishers to edit a volume of EXS on Cancer. This invitation undoubtedly derived from my articles in Cellular and Molecular Life Sciences in 2002 and 2003 on the relationships between the morphology, aetiology and pathogenesis of tumours, especially in relation to genetic instability. After many years of teaching the theories of c- cer in undergraduate medical school courses, it seemed to me that the variably chaotic histopathologic features of tumours parallel in some way, the variably unstable genomes of tumour cells, which were being discovered in the 1990s. Thus the title of the volume has come to include morphology, carcinogenesis and genetic instability. The invitation came while I was working with Herrn Dr. med. Hubertus Jersmann (MD Düsseldorf, PhD, now Senior Lecturer in Medicine of the University of Adelaide) and Professor Brian Coghlan (Emeritus Professor of German, the University of Adelaide), on the work of the nineteenth century cancer pathologists, especially David Paul von Hansemann (1858–1920). With the delivery of the manuscripts from the authors of the chapters, it became obvious that a background chapter for the volume could include some of the material which we had “uncovered” together. Because of this, chapter 1 is authored by the three of us, and the “new” material figures prominently. |
Cuprins
a background | 1 |
Abnormalities of chromatin in tumor cells | 25 |
Aneuploidy stem cells and cancer | 49 |
The mode of action of organic carcinogens on cellular structures | 65 |
Metal ions and carcinogenesis | 97 |
Actions of ultraviolet light on cellular structures | 131 |
Actions of radiation on living cells in the post bystander era | 159 |
Viral carcinogenesis and genomic instability | 179 |
mechanisms and therapeutic implications | 223 |
a conceptual overview | 269 |
Effects of ionizing radiation on cellular structures induced instability and carcinogenesis | 293 |
Genetic instability in human tumors | 303 |
Molecular mechanisms of human carcinogenesis | 321 |
Mechanisms of abnormal gene expression in tumor cells | 351 |
363 | |
apoptosis in tumors | 201 |
Alte ediții - Afișează-le pe toate
Cancer: Cell Structures, Carcinogens and Genomic Instability Leon P. Bignold Previzualizare limitată - 2006 |
Cancer: Cell Structures, Carcinogens and Genomic Instability Leon P. Bignold Nu există previzualizare disponibilă - 2009 |
Termeni și expresii frecvente
abnormalities Acad Sci USA acid activity adducts alterations aneuploidy angiogenesis angiogenic angiostatin anti-angiogenic apoptosis apoptotic arsenic binding Biochem Biol Chem cadmium cancer cells Cancer Res carcinogenesis carcinogenic carcinoma caspase Cell Biol cell lines cellular centrosome checkpoint chromatin chromium chromosomal instability colorectal cancer dimers DNA damage DNA methylation DNA repair dose effects Eker rat endostatin endothelial cells endothelial growth factor enzymes epigenetic epithelial exposure fibroblasts formation function gene expression genetic genomic instability HDAC Hino histone human cancer inactivation induced inhibition inhibitor interaction involved irradiation kinase lesions leukemia lung malignant mechanisms mice microsatellite mitotic molecular mutations Natl Acad Sci nickel normal nucleotide Oncogene pathway phenotype phosphorylation Proc Natl Acad proliferation protein radical reactions receptor regulation renal role sequence somatic specific stem cells target telomerase telomere tion tissue toxicity Toxicol Tsc2 tumor cells tumor suppressor gene tumorigenesis vascular endothelial growth VEGF vitro vivo
Pasaje populare
Pagina 347 - Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomaki P, Sistonen P, Aaltonen LA, Nystrom-Lahti M...
Pagina 318 - Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.