Advances in Drug Discovery TechniquesAlan L. Harvey CRC Press, 15 aug. 1998 - 222 pagini A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics. |
Cuprins
Drug Discovery by Using Molecular Biology to Reprogramme | 7 |
an Overview | 13 |
References | 23 |
Discovery of Specific Tyrosine Kinase Inhibitors from Microbial | 39 |
a Vehicle for Drug Discovery | 48 |
Acknowledgements | 63 |
888888 | 88 |
References | 95 |
5 | 111 |
References | 137 |
New Methods for Structurebased De Novo Drug Design | 143 |
Acknowledgements | 163 |
Antisense Oligonucleotide Therapeutics | 173 |
| 205 | |
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Termeni și expresii frecvente
acid activity affinity American Chemical Society analysis antibiotics antibodies anticancer antisense oligonucleotide approach assays automated Bennett binding biological Bioorganic and Medicinal bryostatin-1 C-raf cancer cell culture cell lines clinical trials combinatorial chemistry combinatorial libraries combinatorial synthesis compounds cytotoxic database derived dose drug design drug discovery effects enzyme extracts Figure fluorescence gene high throughput screening human identified inhibition inhibitors interaction ISIS isolated Journal of Medicinal Journal of Organic large numbers lead ligand marine matrix metalloproteinases Medicinal Chemistry Medicinal Chemistry Letters metabolites mice MMPs molecules Monia mRNA natural products novel novo design optimization PDGF peptide pharmaceutical pharmacokinetics Pharmacology pharmacophore phosphorothioate oligodeoxynucleotides PKC-a plant cell cultures plate polyketide potential PRO_SELECT reagents receptor Research samples secondary metabolites sensor chip Solid phase synthesis solution specific sponge Streptomyces stromelysin structure studies substituents Sunillin surface plasmon resonance synthetic targets techniques Tetrahedron Letters therapeutic tion tissue tumour tyrosine kinase vivo
Pasaje populare
Pagina 199 - Howe, LR, Leevers, SJ, Gomez, N., Nakielny, S., Cohen, P., and Marshall, CJ Activation of the MAP kinase pathway by the protein kinase raf.
Pagina 199 - Ihara, A. (1992) Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science 255, 1125-1127.